Coumarins and derivatives
Medchemexpress LLC 4-Hydroxycoumarin | 1076-38-6 | MFCD00006856 | 10MM 1ML
4-Hydroxycoumarin | 1076-38-6 | MFCD00006856 | 10MM 1ML
Medchemexpress LLC 6-Hydroxycoumarin | 6093-68-1 | 1 G
6-Hydroxycoumarin is a coumarin with a broad spectrum of biological activities, including anti-inflammatory, anti-pyretic, anti-oxidant, vasodilator, anti-amoebic, anti-bacterial, anti-fungal, bacteriostatic, and antitumor properties. It has shown cytotoxicity against various human cancer cell lines such as COLO 205, HCT-116, HL-60, SK-MEL-28, and SK-MEL3.
- Exhibits anti-inflammatory, anti-pyretic, and anti-oxidant effects
- Functions as a vasodilator
- Displays anti-amoebic, anti-bacterial, anti-fungal, and bacteriostatic activities
- Possesses antitumor activity
- Demonstrates cytotoxicity against multiple human cancer cell lines
- Intended for research use only
Medchemexpress LLC 4-Hydroxycoumarin | 1076-38-6 | 250 G
4-Hydroxycoumarin is an orally active coumarin derivative and a versatile heterocyclic scaffold used in the synthesis of various organic compounds. It exhibits both electrophilic and nucleophilic properties. It is identified as an HIV protease inhibitor and tyrosine kinase inhibitor, and also demonstrates anti-inflammatory, antibacterial, and anti-tumor effects.
- Acts as an HIV protease inhibitor
- Acts as a tyrosine kinase inhibitor
- Exhibits anti-inflammatory effects
- Exhibits antibacterial effects
- Exhibits anti-tumor effects
- Disrupts actin cytoskeleton in B16-F10 melanoma cells
- Reduces adhesion and motility to extracellular matrix proteins
- Inhibits tumor growth and improves survival rate in melanoma mice
- Reduces symptoms in a rat model of trinitrobenzene sulfonic acid-induced colitis
Medchemexpress LLC 4-Hydroxycoumarin | 1076-38-6 | 50 G
4-Hydroxycoumarin is an orally active coumarin derivative, a versatile heterocyclic scaffold used in synthesizing various organic compounds. It possesses both electrophilic and nucleophilic properties. It acts as an HIV protease inhibitor and tyrosine kinase inhibitor, and exhibits anti-inflammatory, antibacterial, and anti-tumor effects.
- Orally active coumarin derivative
- Versatile heterocyclic scaffold for organic compound synthesis
- Possesses both electrophilic and nucleophilic properties
- Acts as an HIV protease inhibitor
- Acts as a tyrosine kinase inhibitor
- Exhibits anti-inflammatory effects
- Exhibits antibacterial effects
- Exhibits anti-tumor effects
Medchemexpress LLC 7-Hydroxycoumarin-4-acetic acid | 6950-82-9 | 250 MG
7-Hydroxycoumarin-4-acetic acid is a pH-indicator dye that is covalently bound to bovine serum albumin (BSA) at the positions of reactive amino groups (λmax=326 nm). This product is intended for research use only.
- pH-indicator dye
- Covalently bound to bovine serum albumin (BSA)
- White to off-white solid
- Molecular weight 220.18
- Chemical formula C11H8O5
- Emission (Em): 450
- Excitation (Ex): 415
- Store at 4°C, protect from light
- In solvent, store at -80°C for 6 months or -20°C for 1 month, protect from light
Medchemexpress LLC 7-Ethoxy-4-methylcoumarin | 87-05-8 | 99.44% | 50 G
7-Ethoxy-4-methylcoumarin is a coumarin derivative that functions as a substrate probe for mammalian cytochromes P450 1A1, 2B4, and 2B6.
- Coumarin derivative
- Substrate probe of mammalian cytochromes P450 1A1, 2B4 and 2B6
- Molecular weight: 204.22
- Formula: C12H12O3
- Appearance: Solid
- Color: White to off-white
- SMILES: O=C1C=C(C)C2=CC=C(OCC)C=C2O1
Selleck Chemical LLC 4-Methylesculetin S4966-25mg
4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level
eMolecules 529-84-0 | 4-Methylesculetin | Combi-Blocks | MFCD00006859 | 192.170 | C10H8O4 | 95.000 | Cc1cc(=O)oc2cc(O)c(O)cc12 | 1g | 415500297
4-Methylesculetin | Combi-Blocks | 529-84-0 | MFCD00006859 | 192.170 | C10H8O4 | 95.000 | Cc1cc(=O)oc2cc(O)c(O)cc12 | 1g | 415500297
Medchemexpress LLC Linarin (buddleoside) | 480-36-4 | MFCD00151178 | 98.0% | 592.55 | C28H32O14 | 10 MG
Linarin (buddleoside) is a naturally occurring flavonoid glycoside and an orally active, selective acetylcholinesterase (AChE) inhibitor. It has reported anti-inflammatory, antioxidant, sedative, bone differentiation, antitumor, antibacterial, and antiviral activities and is used in research on nervous system disorders, osteoporosis, and cancer.
- Natural flavonoid glycoside, also known as buddleoside.
- Selective acetylcholinesterase (AChE) inhibitor, orally active.
- CAS 480-36-4; formula C28H32O14; molecular weight 592.55.
- Purity typically 98.0% as supplied.
- White to off-white solid; soluble in DMSO (≈250 mg/mL).
- Storage: protect from light; short-term 4°C; in solution -20°C to -80°C as specified.
- Supplied in small research quantities suitable for in vitro and in vivo studies.
Medchemexpress LLC Esculetin | 305-01-1 | 99.79% | 178.14 | 1 ML
Esculetin is an active ingredient extracted mainly from the bark of *Fraxinus rhynchophylla*. It primarily functions by inhibiting the PI3K/Akt pathway, which affects platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching. Additionally, Esculetin demonstrates antioxidant, anti-inflammatory, and antitumor properties, making it a subject of various research applications. It is intended for research use only and not for medical or patient use.
- Inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cell (ASMC) proliferation and migration.
- Demonstrates antioxidant activity.
- Exhibits anti-inflammatory effects.
- Possesses antitumor activities.
- Targets PI3K pathway.
- Induces apoptosis in certain cancer cell types.
- Ameliorates skin lesions in psoriatic mice models.
TARGETMOL CHEMICALS INC HX 531 10MG
Also available in 1 mg 5 mg 25 mg 50 mg and bulk. Please contact Fisher for quotes. HX 531 is a potent antagonist of the retinoid X receptor with an IC50 value of 18 nM. purity: 99%
Apexbio Technology LLC 6,7-Dihydroxycoumarin 305-01-1 10mM (in 1mL DMSO)
6 7-Dihydroxycoumarin (CAS 305-01-1) also known as esculetin is a naturally occurring coumarin derivative extracted from Aesculus hippocastanum Linn This compound exhibits notable antioxidant activity primarily by scavenging reactive oxygen species and inhibiting lipid peroxidation Additionally 6 7-dihydroxycoumarin has been studied for its modulatory effects on various cellular signaling pathways implicated in inflammation and apoptosis Its applications in biomedical research include investigations into oxidative stress inflammation and related disease models The compound is soluble in ethanol and dilute alkali and should be stored in a sealed cool and dry environment to preserve stability
Apexbio Technology LLC 6,7-Dihydroxycoumarin 305-01-1 20mg
6 7-Dihydroxycoumarin (CAS 305-01-1) also known as esculetin is a naturally occurring coumarin derivative extracted from Aesculus hippocastanum Linn This compound exhibits notable antioxidant activity primarily by scavenging reactive oxygen species and inhibiting lipid peroxidation Additionally 6 7-dihydroxycoumarin has been studied for its modulatory effects on various cellular signaling pathways implicated in inflammation and apoptosis Its applications in biomedical research include investigations into oxidative stress inflammation and related disease models The compound is soluble in ethanol and dilute alkali and should be stored in a sealed cool and dry environment to preserve stability